The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 111, 145-153, ©Copyright 1960, by The Rockefeller Institute

ARTICLE

STUDIES IN THE PATHOGENESIS OF EXPERIMENTAL DYSENTERY INTOXICATION : PRODUCTION OF LESIONS BY INTRODUCTION OF TOXIN INTO THE CEREBRAL VENTRICLES



Abraham Penner M.D.1 and Alice Ida Bernheim M.D.1

1 From the Department of Pathology, The Mount Sinai Hospital, New York

The introduction of Shiga toxin into the ventricular system of the brain with major location in the third ventricle resulted in a response similar to that following the administration of the toxin either intravenously or by cross-circulation. The intravenous administration at the dosage level employed would have elicited no response. These observations lend support to the hypothesis that Shiga toxin activates some mechanisms in the central nervous system which are capable of producing visceral lesions. These mechanisms are those which control the vasomotor components of homeostasis. This hypothesis permits an explanation of the proximo-distal and intramural features of the lesion.

Submitted on October 6, 1959


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