The Journal of Experimental Medicine
ThymUS '08
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The Journal of Experimental Medicine, Vol 110, 827-844, Copyright, 1959, by The Rockefeller Institute

ARTICLE

SEQUENTIAL CELLULAR CHANGES PRODUCED BY TYPES 5 AND 7 ADENOVIRUSES IN HELA CELLS AND IN HUMAN AMNIOTIC CELLS : CYTOLOGICAL STUDIES AIDED BY FLUORESCEIN-LABELLED ANTIBODY



Georgiana S. Boyer M.D.1, Floyd W. Denny Jr. M.D.1, and Harold S. Ginsberg M.D.1

1 From the Departments of Preventive Medicine, Medicine and Pediatrics, School of Medicine, Western Reserve University, and the University Hospitals, Cleveland

The sequential cytological changes which develop in tissue culture cells infected with adenovirus types 5 and 7 are described and compared with those produced by adenovirus types 1, 2, 3, and 4. The evidence that is presented indicates that types 1, 2, and 5 belong to one major subdivision of the adenovirus group and types 3, 4, and 7 to another. That the host cell nucleus is the principal site of adenovirus synthesis has been confirmed by fluorescent antibody studies. They have demonstrated the occurrence of type-specific adenovirus antigen in the characteristic intranuclear inclusions and other virus-induced structures reported to contain virus-like particles or shown by electronmicroscopy.

Submitted on July 20, 1959


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