The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 110, 731-750, Copyright, 1959, by The Rockefeller Institute

ARTICLE

INACTIVATION OF ENDOTOXIN BY A HUMORAL COMPONENT : IV. ALTERATION IN THE IMMUNOLOGICAL PROPERTIES OF TYPHOID ENDOTOXIN



Maurice Landy Ph.D.1, Robert-John Trapani 1, and Murray J. Shear Ph.D.1

1 From the Laboratory of Chemical Pharmacology, National Cancer Institute, Bethesda, Maryland

The immunological properties of typhoid endotoxin were investigated after incubating it with serum under conditions in which EDC (endotoxin-detoxifying component) was operative. Brief interaction of endotoxin in vitro with this system in serum (human, rabbit, mouse) abolished its antigenicity for rabbits. Suitable modification of the host permitted separate elicitation of toxic and antigenic responses to typhoid endotoxin. Endotoxin altered by EDC was still capable of precipitating specific antibody; moreover, it did so in a manner which resembled that of the haptenic polysaccharide.

Submitted on July 13, 1959


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