The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 109, 475-485, Copyright, 1959, by The Rockefeller Institute

ARTICLE

THE MAMMALIAN CELL-VIRUS RELATIONSHIP : I. ATTACHMENT OF POLIOVIRUS TO CULTIVATED CELLS OF PRIMATE AND NON-PRIMATE ORIGIN



Leroy C. McLaren Ph.D.1, John J. Holland Ph.D.1, and Jerome T. Syverton M.D.1

1 From the Department of Bacteriology and Immunology, University of Minnesota, Minneapolis

Primary or established strain cultures of a variety of primate cells that were susceptible to cytopathic infection strongly adsorbed poliovirus. Insusceptible non-primate cells in primary or established-strain culture did not so adsorb virus (or propagate it), with exception of the ERK-1 embryo rabbit kidney strain. All tested cells, regardless of type or susceptibility, adsorbed about 1 per cent of input virus, which became cell-associated (CAV) without loss of infectivity. In combination with susceptible or insusceptible cells, CAV was only about 90 per cent neutralized by homotypic antiserum. CAV eluted continuously from non-susceptible cells with continued incubation; eluted virus gave rise to infection and new CAV to the same degree in susceptible cells as did original virus.

Submitted on January 18, 1959


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