The Journal of Experimental Medicine
Janeway's Immunobiology 7th Edition
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The Journal of Experimental Medicine, Vol 109, 127-143, Copyright, 1959, by The Rockefeller Institute

ARTICLE

THE BIOLOGICAL ACTIVITY OF SOLUBLE ANTIGEN-ANTIBODY COMPLEXES : II. PHYSICAL PROPERTIES OF SOLUBLE COMPLEXES HAVING SKIN-IRRITATING ACTIVITY



Kimishige Ishizaka M.D.1, Teruko Ishizaka M.D.1, and Dan H. Campbell Ph.D.1

1 From the Division of Chemistry and Chemical Engineering, The California Institute of Technology, Pasadena

Soluble BSA-anti-BSA complexes, formed in antigen excess, give immediate skin reactions in normal guinea pigs. The mechanism of the reaction is not that of passive or reversed passive anaphylaxis. The complex itself is toxic.

Skin activity of the complex depends on its composition. It has become obvious that the complex composed of two antigen molecules and one antibody molecule, (Ag2Ab), does not have the activity, whereas, Ag3Ab2 and more complicated complexes do.

The role of complement as well as speculation on the structural changes of antibody-antigen complexes is presented.

 Submitted on September 24, 1958


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