The Journal of Experimental Medicine
MBL International Tel: 800.200.5459 CLICK HERE
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Luse, S. A.
Right arrow Articles by Smith, M. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Luse, S. A.
Right arrow Articles by Smith, M. G.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
The Journal of Experimental Medicine, Vol 107, 623-632, Copyright, 1958, by The Rockefeller Institute for Medical Research New York

ARTICLE

ELECTRON MICROSCOPY OF SALIVARY GLAND VIRUSES

Sarah A. Luse M.D.1 and Margaret G. Smith M.D.1

1 From the Departments of Pathology and Anatomy, Washington University School of Medicine, St. Louis

A human and a mouse strain of the salivary gland virus have been examined by electron microscopy. The human strain was transmitted, prior to examination, to tissue cultures derived from human myometrial cells, while the mouse strain was examined in mice inoculated intraperitoneally.

The nuclear forms associated with both strains of virus were morphologically similar. Nuclear inclusions, composed of particles interspersed with dense clumped chromatin, were a striking feature of infected cells. The cytoplasmic forms were of 2 types—one a 300 to 500 mµ homogeneous dense spherical form, and the other a target-like form composed of a central dense dot in a pale zone surrounded by a dense shell—the entire configuration measuring 100 to 180 mµ. The target-like particle appeared to be identical in both strains. The spherical cytoplasmic forms in cells infected with the human strain appeared to be solid, while in cells infected with the mouse strain there was evidence of formation of target-like forms within the spheres.

Possible mechanisms by which infection of the cell may occur, as well as possible mechanisms and sites of multiplication of virus, are discussed.

 Submitted on December 22, 1957


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS