The Journal of Experimental Medicine
Keystone Symposia
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The Journal of Experimental Medicine, Vol 107, 305-318, Copyright, 1958, by The Rockefeller Institute for Medical Research New York

ARTICLE

STUDIES ON THE PATHOGENESIS OF FEVER : V. THE RELATION OF CIRCULATING ENDOGENOUS PYROGEN TO THE FEVER OF ACUTE BACTERIAL INFECTIONS



M. Kenton King M.D.1 and W. Barry Wood Jr. M.D.1

1 From the Department of Microbiology, Johns Hopkins University School of Medicine and School of Hygiene and Public Health, Baltimore

An endogenous pyrogen, which is indistinguishable from leucocytic pyrogen, has been demonstrated in the blood streams of rabbits with fevers caused by experimental pneumococcal and streptococcal infections. Like the endogenous pyrogen previously detected in the serum of animals with fever produced by the intravenous injection of typhoid vaccine, the newly discovered circulating factor acts directly upon the thermoregulatory centers of the brain. Its origin from polymorphonuclear leucocytes at the site of infection appears to have been established.

The possible relationship of this circulating endogenous pyrogen to the pathogenesis of other forms of fever is discussed.

 Submitted on October 1, 1957


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