The Journal of Experimental Medicine
BioLegend: Antibody Reagents
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The Journal of Experimental Medicine, Vol 107, 279-289, Copyright, 1958, by The Rockefeller Institute for Medical Research New York

ARTICLE

STUDIES ON THE PATHOGENESIS OF FEVER : III. THE LEUCOCYTIC ORIGIN OF ENDOGENOUS PYROGEN IN ACUTE INFLAMMATORY EXUDATES



M. Kenton King M.D.1 and W. Barry Wood Jr. M.D.1

1 From the Department of Microbiology, Johns Hopkins University School of Medicine and School of Hygiene and Public Health, Baltimore

The evolution of an acute inflammatory exudate produced in rabbits by the intraperitoneal injection of saline has been described. Evidence has been presented that polymorphonuclear leucocytes release endogenous pyrogen into the cell-free fluid of the exudate. Leucocytes from such exudates have also been shown to release pyrogen into the surrounding medium during incubation in vitro at 37°C. The results of parallel cytological studies have provided evidence which suggests that the leucocytes give up their pyrogen while functionally intact.

These observations add further support to the hypothesis that polymorphonuclear leucocytes play a significant role in the pathogenesis of fever.

 Submitted on October 1, 1957


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