The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 107, 211-218, Copyright, 1958, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE IN VITRO ACTION OF HYDROCORTISONE ON LEUCOCYTE MIGRATION

Melvin M. Ketchel Ph.D.1, Cutting B. Favour M. D.1, Somers H. Sturgis M.D.1, and With the Technical Assistance of Aurelia C. Koros and Frances Mao

1 From the Departments of Surgery, Harvard Medical School and the Peter Bent Brigham Hospital, Boston

Hydrocortisone inhibits the ameboid migration of human leucocytes when added in vitro. The dose-response curve for the reaction between this steroid and leucocytes can be best expressed by a logarithmic plot of the steroid concentrations.

Tetrahydrocortisone and desoxycorticosterone had no effect on in vitro leucotyte migration.

 Submitted on October 6, 1957


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