The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 107, 55-61, Copyright, 1958, by The Rockefeller Institute for Medical Research New York

ARTICLE

STUDIES ON THE EFFECT OF TRITON (WR-1339) ON GUINEA PIG TISSUES : III. TUBERCULIN HYPERSENSITIVITY AND IN VITRO CYTOLYSIS OF LEUCOCYTES BY TUBERCULIN



Robert A. Patnode Ph.D.1 and Paul C. Hudgins 1

1 From the Tuberculosis Research Laboratory, Veterans Administration Hospital, Washington, D. C.

The administration of triton WR-1339 (300 mg./kg. subcutaneously) to tuberculin-sensitive guinea pigs 2 hours before the intradermal injection of PPD depresses slightly their skin sensitivity to tuberculin and essentially obliterates the lytic effect of tuberculin on their circulating leucocytes. When leucocytes from tuberculin-sensitive guinea pigs are exposed to triton in vitro at a concentration level attainable in vivo the cells are partially protected against lysis by PPD.

Submitted on August 5, 1957


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