The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 105, 529-537, Copyright, 1957, by The Rockefeller Institute for Medical Research New York

ARTICLE

BACTERICIDAL ACTIVITY OF RAT LEUCOCYTIC EXTRACTS : II. CHARACTERIZATION OF THE BACTERICIDAL SUBSTANCE IN LEUCOCYTE MITOCHONDRIAL EXTRACTS



M. Fishman Ph.D.1, L. J. Cole 1, and M. S. Silverman Ph.D.1

1 From the Division of Biological and Medical Sciences, United States Naval Radiological Defense Laboratory, San Francisco

The bactericidal substance present in mitochondrial extracts from rat leucocytes was found to be non-dialyzable, fractionated at 30 per cent (NH4SO4 saturation and was able to withstand temperatures up to 100°C.

The tentative identification of a lipoprotein as the responsible bactericidal substance is based on various observations; an ultraviolet absorption at a peak associated with alpha, beta unsaturated fatty acids, 205 to 208 mµ, inactivation of the bactericidal substance by ether treatment at –70°C. but not at 0°C. and inhibition of the bactericidal activity with lipase treatment as well as with trypsin.

 Submitted on January 27, 1957


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