The Journal of Experimental Medicine, Vol 105, 453-462,
Copyright, 1957, by The Rockefeller Institute for Medical Research New York
HOMOLOGOUS IMMUNOLOGICAL STUDIES OF OCULAR LENS
:
II. BIOLOGICAL ASPECTS
S. P. Halbert M.D.1,
D. Locatcher-Khorazo M.D.1,
L. Swick 1,
R. Witmer M.D.1,
B. Seegal M.D.1, and
P. Fitzgerald 1
1 From the Departments of Ophthalmology and Microbiology, Columbia University, College of Physicians and Surgeons, and the Institute of Ophthalmology, Presbyterian Hospital, New York
Lenses of rabbits with high titers of homologous lens antibodies showed no lesions, even after repeated paracentesis of the anterior chamber in a number of such animals. In these instances, lens antibodies were shown to be present in both the primary and secondary aqueous humors.
A small group of rabbits with high homologous anti-lens antibody titers were successfully bred. These had been immunized with adult rabbit lens pools in Freund's adjuvants, and had high antibody levels throughout pregnancy. No significant congenital lens lesions were found when these 18 young from 3 litters were compared with the 17 young from 3 litters of mothers who had no detectable anti-lens antibody through gestation. The latter group of does had received the equivalent doses of homologous lens in saline.
Patients with cataract did not show demonstrable anti-lens antibodies in their serum when tested by the agar precipitin technic against cataractous human lens homogenates.
Submitted on January 22, 1957
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