The Journal of Experimental Medicine
Avanti Polar Lipids
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The Journal of Experimental Medicine, Vol 104, 707-725, Copyright, 1956, by The Rockefeller Institute for Medical Research New York

ARTICLE

THE PROPERDIN SYSTEM AND IMMUNITY : VI. THE INACTIVATION OF NEWCASTLE DISEASE VIRUS BY THE PROPERDIN SYSTEM



Ralph J. Wedgwood M.D.1, Harold S. Ginsberg M.D.1, and Louis Pillemer Ph.D.1

1 From the Departments of Pediatrics and Preventive Medicine, School of Medicine, and from the Institute of Pathology, Western Reserve University, Cleveland

Detailed experiments are presented which indicate that the properdin system is an inhibitor of Newcastle disease virus. Viral inhibition required all known components of the properdin system: properdin, all four components of complement and magnesium; the removal of any one constituent resulted in a loss of inhibition; the replacement of the constituent restored antiviral effect. The inhibition of virus was temperature-dependent. The process of inhibition by serum resulted in a decrease in the amount of properdin available in the serum without any measurable effect on the components of complement. The prolonged incubation of inactive serum-virus mixtures with cation-exchange resin resulted in the restoration of some, but not all, of the hemagglutinating activity of the virus. The requirements of the properdin system and the implication of these findings were discussed.

Submitted on July 9, 1956


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