The Journal of Experimental Medicine
Janeway's Immunobiology 7th Edition
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The Journal of Experimental Medicine, Vol 104, 501-515, Copyright, 1956, by The Rockefeller Institute for Medical Research New York

ARTICLE

GROWTH CHARACTERISTICS OF INFLUENZA VIRUS. PROPERTIES OF THE INITIAL CELL-VIRUS COMPLEX

Nakao Ishida M.D.1 and W. Wilbur Ackermann Ph.D.1

1 From the Department of Epidemiology and Virus Laboratory, School of Public Health, University of Michigan, Ann Arbor

The rate has been determined at which the initial stable complex is formed between cells of the chorioallantoic membrane and the PR8 strain of type A influenza virus.

Characterization of the complex revealed the following properties: (a) stability to dilution and to simple washing with buffered saline, (b) insensitivity to the action of receptor-destroying enzyme (obtained from cholera vibrio), (c) sensitivity to the inhibitory effect of anti-viral immune serum, (d) formation of the complex at low temperatures, 3°C., (e) accompanied by a loss of detectable viral infectivity from the reaction mixture, (f) stability at 3°C. but transformation at 37°C. to a state which is resistant to the inhibitory action of a specific anti-viral serum. The rate of this latter transformation has been determined. The infectious process in more than 50 per cent of the cells can be influenced by immune serum 2 hours after the completion of the initial reaction with virus.

 Submitted on June 15, 1956


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