The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 103, 545-552, Copyright, 1956, by The Rockefeller Institute for Medical Research New York

ARTICLE

STUDIES ON NON-PRECIPITATING ANTIBODY : II. CIRCULATING ANTIBODY-ANTIGEN COMPLEX FOLLOWING REPEAT INJECTIONS OF ANTIGEN



Ludwig A. Sternberger M.D.1

1 From the Allergy Research Laboratory, Department of Medicine, Northwestern University Medical School, Chicago, and the Division of Laboratories and Research, New York State Department of Health, Albany

Reinjection of antigen into immunized rabbits usually results in an immediate increase of circulating antibody-antigen complex. This immediate formation of complex seems to depend upon the presence of non-precipitating antibody before reinjection. The complex disappears by the 2nd day after reinjection and reappears between the 4th to 7th day. This is earlier than its first appearance after a primary injection and may indicate an anamnestic response of the non-precipitating antibody responsible for the formation of circulating antibody-antigen complex.

Submitted on January 18, 1956


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