The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 103, 425-438, Copyright, 1956, by The Rockefeller Institute for Medical Research New York

ARTICLE

RATES OF ANTIBODY SYNTHESIS DURING FIRST, SECOND, AND HYPERIMMUNE RESPONSES OF RABBITS TO BOVINE GAMMA GLOBULIN

Frank J. Dixon M.D.1, Paul H. Maurer Ph.D.1, William O. Weigle 1, and Maria P. Deichmiller 1

1 Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh

Determinations of the rates of antibody synthesis during first, second, and hyperimmune responses to bovine gamma globulin using S35-labelle aminod acids indicate the following:

1. In all three responses the rate of antibody synthesis increases while antigen is circulating and then begins to decline rapidly after elimination of detectable circulating antigen.

2. The initial rates of decline of antibody synthesis are approximately the same for all three responses.

3. There is a relatively persistent source of antibody production which appears after repeated stimulation and increases in proportion to the number of repeated stimuli.

 Submitted on December 13, 1955


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