The Journal of Experimental Medicine
Janeway's Immunobiology 7th Edition
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The Journal of Experimental Medicine, Vol 103, 49-56, Copyright, 1956, by The Rockefeller Institute for Medical Research New York

ARTICLE

REDUCTION OF EXCESS CHOLESTEROL IN THE RABBIT AORTA BY INHIBITION OF ENDOGENOUS CHOLESTEROL SYNTHESIS

George L. Curran M.D.1 and Richard L. Costello 1

1 From the Department of Medicine, University of Kansas School of Medicine, Kansas City

Hepatic cholesterol synthesis in rabbits, as measured by the incorporation of C14-labelled acetate, was inhibited by addition of non-toxic amounts of vanadyl sulfate (0.05 per cent VOSO4·2H2O) to the diet. This diet reduced excess aortic cholesterol in cholesterol prefed rabbits when fed during the 6 weeks immediately following a 4 week period of cholesterol feeding.

Submitted on August 29, 1955


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