The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 102, 807-822, Copyright, 1955, by The Rockefeller Institute for Medical Research New York

ARTICLE

GLOMERULONEPHRITIS PRODUCED IN DOGS BY SPECIFIC ANTISERA : II. PATHOLOGIC SEQUENCES FOLLOWING THE INJECTION OF RABBIT ANTIDOG-PLACENTA SERUM OR RABBIT ANTIDOG-KIDNEY SERUM



Margaret Bevans M.D.1, Beatrice Carrier Seegal M.D.1, and Ruth Kaplan 1

1 From the Departments of Pathology, Medicine, and Microbiology, College of Physicians and Surgeons and the Columbia University Research Service, Goldwater Memorial Hospital, Columbia University, New York

The intravenous injection of rabbit antidog-placenta or antidog-kidney serum produced immediate evidence of glomerulonephritis in dogs. The lesions produced by the two agents were indistinguishable.

The glomerulonephritis so induced may terminate in death within 8 days, may progress to a chronic form or may heal. The acute phase of the nephritis was usually associated with severe exudative and necrotizing renal lesions, while the pathologic sequences in surviving dogs were essentially reparative. However, 1 dog of 8 in the chronic phase developed a progressive chronic nephritis and died in uremia.

 Submitted on June 28, 1955


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