The Journal of Experimental Medicine
PBL InterferonSource
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tishkoff, G. H.
Right arrow Articles by Whipple, G. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tishkoff, G. H.
Right arrow Articles by Whipple, G. H.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
The Journal of Experimental Medicine, Vol 102, 713-723, Copyright, 1955, by The Rockefeller Institute for Medical Research New York

ARTICLE

RED CELL STROMA AND HEMOGLOBIN METABOLISM IN ANEMIC DOGS : REGENERATION OF RED CELL PROTEINS LABELED WITH C14 LYSINE



G. H. Tishkoff M.D.1, C. L. Yuile M.D.1, F. S. Robscheit-Robbins Ph.D.1, and G. H. Whipple M.D.1

1 From the Department of Pathology, The University of Rochester School of Medicine and Dentistry, Rochester, New York

Red cell stroma protein and hemoglobin can be labeled by feeding C14 lysine during periods of active blood regeneration following anemia.

Stroma proteins are produced and a maximum concentration of the C14 label appears 2 to 3 days earlier than with hemoglobin,—which is to say that stroma building precedes hemoglobin construction.

The concentration of isotope in stroma protein may exceed its concentration in hemoglobin during regeneration following anemia due to blood loss. Diets favorable for hemoglobin regeneration may force the hemoglobin isotope concentration above that of the stroma protein.

In hemolytic anemias great reserves of red cell building material are stored in the body. These stores may modify the curves of isotope concentration in red cells during the recovery periods.

When finally formed, the mature red cells show little or no evidence of participation in general body protein metabolism during their life in the circulation.

 Submitted on August 1, 1955


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS