The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 102, 699-704, Copyright, 1955, by The Rockefeller Institute for Medical Research New York


ARTICLE

GLUTAMIC-OXALOACETIC TRANSAMINASE ACTIVITY OF SERUM IN MICE WITH VIRAL HEPATITIS

Charlotte Friend Ph.D.1, Felix Wróblewski M.D.1, and John S. La Due M.D.1

1 From the Sloan-Kettering Institute for Cancer Research, New York

Experimental infectious mouse hepatitis is associated with an increase in glutamic-oxaloacetic transaminase activity of the serum (SGO-T).

A relationship appears to exist between the rise in SGO-T activity and (a) the size of the virus inoculum, (b) the blood virus titer, and (c) the degree of liver necrosis.

Trauma to the liver following partial hepatectomy results in a rise in SGO-T activity in mice.

Although mouse hepatitis differs from human hepatitis in the incubation period, histological changes, and natural course, both infections bring about comparable changes in SGO-T activity.

Submitted on August 17, 1955


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