The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 102, 647-653, Copyright, 1955, by The Rockefeller Institute for Medical Research New York

ARTICLE

A METHOD FOR COUPLING PROTEIN ANTIGENS TO ERYTHROCYTES : II. USE OF THE METHOD IN THE DIAGNOSIS OF TUBERCULOSIS



Leon R. Cole M.D.1, J. Jay Matloff M.D.1, and Virginia R. Farrell 1

1 From the Departments of Medicine, Peter Bent Brigham Hospital, and Harvard University Medical School, and the Departments of Medicine, Boston City Hospital, and Boston University Medical School, Boston

A serological technique, using formalinized red cells coupled to tuberculin PPD as antigen, has been assayed in a trial series of 124 tuberculous and 139 non-tuberculous patients. The stability of the antigen preparation, and the omission of an adsorption procedure for the removal of isoagglutinins facilitated the performance of the test. The results indicate that the technique warrants further trial as a diagnostic criterion of infection tuberculosis.

Submitted on August 3, 1955


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