The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 102, 601-616, Copyright, 1955, by The Rockefeller Institute for Medical Research New York

ARTICLE

AN INFECTIOUS HEPATITIS OF UNDETERMINED ORIGIN IN MICE : I. DESCRIPTION OF THE DISEASE



Janet Jordan M.D.1, George S. Mirick M.D.1, and With the Technical Assistance of Marjorie G. Huck

1 From the Department of Medicine, The Johns Hopkins University School of Medicine, Baltimore

Serial intraperitoneal passage in mice of a saline extract of the pooled livers, spleens, and kidneys of such animals has led to the demonstration after three or more passages of a transmissible agent causing hepatitis. The mice developed an illness after 3 to 4 weeks characterized by hepatosplenomegaly, and serous ascites. Spontaneous diuresis and recovery usually occurred during the subsequent 2 to 4 weeks.

Histological studies of the livers showed diffuse mononuclear infiltrations, focal accumulations of mononuclear cells, perivascular mononuclear cuffing, dilated sinusoids, and occasionally focal areas of necrosis.

Mice which have recovered from the disease showed no noteworthy resistance to it, and their sera failed to protect against the infectious agent. Attempts to infect rabbits, guinea pigs, monkeys, and embryonated hens' eggs yielded negative results, but young hamsters developed the disease in mild form.

 Submitted on August 3, 1955


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