The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 102, 499-516, Copyright, 1955, by The Rockefeller Institute for Medical Research New York

ARTICLE

STUDIES ON THE PATHOGENESIS OF FEVER : II. IDENTIFICATION OF AN ENDOGENOUS PYROGEN IN THE BLOOD STREAM FOLLOWING THE INJECTION OF TYPHOID VACCINE



Elisha Atkins M.D.1 and W. Barry Wood Jr. M.D.1

1 From the Department of Medicine, Washington University School of Medicine, and the Barnes and Wohl Hospitals, St. Louis

Further studies have been made of a pyrogenic substance which appears in the circulation of rabbits during the course of experimental fever induced by injection of typhoid vaccine. With the use of a passive transfer method and pyrogen-tolerant recipients, the biological properties of this substance have been differentiated from those of the uncleared vaccine in the circulation. The newly identified factor resembles leucocytic pyrogen in the rapidity with which it produces fever and in its failure to exhibit cross-tolerance with bacterial pyrogen. This striking similarity of properties suggests that the circulating factor is of endogenous origin and may arise from cell injury. A close correlation between its presence in the circulation and the existence of fever has been demonstrated.

The possible relationship of these findings to the pathogenesis of fever is evident.

 Submitted on July 7, 1955


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