The Journal of Experimental Medicine
Cytokines in immune regulation
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The Journal of Experimental Medicine, Vol 102, 319-333, Copyright, 1955, by The Rockefeller Institute for Medical Research New York

ARTICLE

PRESSOR SUBSTANCES IN ARTERIAL HYPERTENSION : V. CHEMICAL AND PHARMACOLOGICAL CHARACTERISTICS OF PHERENTASIN



Henry A. Schroeder M.D.1, H. Mitchell Perry Jr. M.D.1, Evie G. Dennis 1, and Laura E. Mahoney 1

1 From the Hypertension Division, Department of Internal Medicine, Washington University School of Medicine, and Barnes Hospital, St. Louis

Some pharmacological and chemical qualities of pherentasin, a vasoconstrictor substance procured from human hypertensive blood, were studied by a new assay method using the spirally cut rabbit aorta. Of a number of drugs tested, six metal-binding agents including hydralazine inactivated the active principle. The material was stable in acid but not in alkali. It was destroyed by drying. Chemical analysis and inactivation procedures suggested the presence of primary amine and considerable sulfur; a peptide linkage was suspected because of inactivation by manganous ion and papain. The material was remarkably resistant to most pharmacological agents and appeared to act directly on smooth muscle.

Submitted on April 27, 1955


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