The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 101, 639-646, Copyright, 1955, by The Rockefeller Institute for Medical Research New York

ARTICLE

A TISSUE FACTOR INFLUENCING SUCCINIC DEHYDROGENASE ACTIVITY IN TUBERCULOUS GUINEA PIGS

S. P. Martin M.D.1, C. D. Cooper M.D.1, S. N. Chaudhuri M.B.B.S.1, and R. Green 1

1 From the Departments of Medicine and Bacteriology, Duke University School of Medicine, Durham

The alterations in succinic dehydrogenase activity during the course of infection with Mycobacterium tuberculosis strains H37Rv and BCG, as well as with dead bacilli, has been described. A tissue factor has been described which is prepared from normal bovine kidney and will restore enzyme activity in vitro. This factor is prepared by chromatographic analysis and contains a nucleotide with an ultraviolet absorption maxima at 250 mµ (pH 3) and a free sulfhydryl group. The role of this factor in the response to tuberculosis is discussed.

Submitted on August 27, 1954


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