The Journal of Experimental Medicine
Cytokines Montreal 2008
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The Journal of Experimental Medicine, Vol 100, 321-328, Copyright, 1954, by The Rockefeller Institute for Medical Research New York

ARTICLE

STUDIES ON ENTRY AND EGRESS OF POLIOMYELITIC INFECTION : VII. EARLY LESIONS IN PERIPHERAL GANGLIA AFTER SIMPLE FEEDING: WITH COMMENTS ON THE POSSIBLE VALUE OF IMMUNIZATION IN PREVENTING NEURAL ENTRY



Harold K. Faber M.D.1 and Luther Dong 1

1 From the Department of Pediatrics, Stanford University School of Medicine, San Francisco

At 56, 60, and 72 hours after simple feeding of poliomyelitis virus, typical, discrete lesions were found in the ganglia supplying the mouth and pharynx, which were most numerous and severe in the Gasserian ganglia. Lesions were also found in the nerve bundles adjacent to the infected ganglia.

The character, localizations, and time of appearance of lesions point to nerve-conducted entry of infection from the mucosa of the mouth and pharynx.

The possibility is suggested that under natural conditions of exposure, in which only small amounts of virus are involved, artificially induced immunity, active and probably passive, may block primary neural entry at the oropharyngeal portal by virtue of antibodies in the overlying mucus.

 Submitted on June 5, 1954


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