The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 100, 247-267, Copyright, 1954, by The Rockefeller Institute for Medical Research New York

ARTICLE

INTERFERENCE BETWEEN POLIOMYELITIS VIRUSES IN TISSUE CULTURE

Nada Ledinko Ph.D.1 and Joseph L. Melnick Ph.D.1

1 From the Section of Preventive Medicine, Yale University School of Medicine, New Haven

The inhibition of multiplication of one poliomyelitis virus by a poliomyelitis virus of another immunologic type has been established by using tissue cultures of monkey testes. The degree of interference varied from none, to partial, to complete, depending upon the time between inoculation of the interfering and the challenge viruses, and the amount of each virus inoculated. Reciprocal interference was demonstrated between Types 1, 2, and 3 poliomyelitis viruses.

Under conditions which resulted in complete suppression of the growth of one poliomyelitis virus by another, interference by poliomyelitis virus with the multiplication of four antigenically distinct "orphan" viruses and of three antigenically related strains of Coxsackie virus could not be demonstrated.

Poliomyelitis virus rendered non-infective by formalin or by irradiation with high energy electrons or with ultraviolet light, or treated so that only traces of residual active virus remained, failed to interfere with the propagation of active homologous virus.

 Submitted on May 15, 1954


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